Past and present clinical trials that researched the effect of specific chemicals, occurring naturally in various food/plant sources, on specific biochemicals partly responsible for fat metabolism and energy expenditure have concluded the following:

Green Tea Extract (95% Polyphenols)


Increased the action of Noradrenaline and the potential to increase fat loss. Dulloo, et,al,,1999. Dulloo, et,al,,2000

Combining polyphenols with caffeine may increase the action of Noradrenaline alone. Dulloo, et,al, 1999. Dulloo, et,al, 2000

Recent studies indicate that a green tea extract can increase thermogenesis and promote fat oxidation beyond that explained by its caffeine alone (Dulloo, et al., 1999). Thermogenesis and fat oxidation are controlled by the sympathetic nervous system and its neurotransmitter norepinephrine (NE). The catechin polyphenols found in green tea act to inhibit catechol-O-methyl-transferase (the enzyme responsible for degrading NE) (Dulloo, et al.,) resulting in a prolonged effect of NE on thermogenesis and fat metabolism (Dulloo, et al., 1999).

Forskohili (Forskolin Ext)


Had a direct effect on T3 to stimulate the metabolic rate.
J Med Chem.1993, 26, 436- 439 Structure Activity Re of Adenylate Cyclase by Forskolin & its derivatives. KB Seamon J.W. Daily. et al.

Forskolin is valued as an adenylate cyclase activator. Adenylate cyclase is the enzyme involved in the production of cAMP. Cyclic AMP induces a chain of biochemical events that trigger an increase in protein kinase. This, in turn, activates hormone sensitive lipase (which is involved in the breakdown of triglycerides) to stimulate the release of fatty acids from body fat. These liberated fatty acids from body fat can be burned for energy, thus helping you lose fat weight.

Chromium chelate


Chromium is an essential trace mineral required for normal protein, fat, and carbohydrate metabolism. Research shows that the typical diet is low in chromium, and that chromium supplements can often help control blood sugar. The correct regulation of blood sugar can assist in promoting weight loss.

Caffeine (Extracted from Guarana)


Inhibits Adenosine (camp) to create lyptopic (fat burning) and metabolic boosting via the actions of Noradrenaline. Colker, C Cur thir res res.. 60.

Early research by David Costill in the late 1970’s suggested that caffeine increases levels of epinephrine (pronounced ep-in-eff-rin) (Costill, et al., 1978), serving to increase the number of fat calories burned for energy. In fact, there is evidence that caffeine can increase the number of fat calories used for energy by around 30% (Spriet, 1995). Because the muscles have more fat to use, carbohydrate metabolism is reduced. Specifically, increases in muscle citrate, acetyl-CoA, and glucose-6-phosphate act to inhibit phosphofructokinase, pyruvate dehydrogenase, and hexokinase, respectively.

Although many individuals believed that coffee or tea will have the same effect, there is evidence suggesting that coffee does not offer the same beneficial effects as caffeine (Graham, et al., 1998). It appears that some component of coffee interferes with the performance enhancing effects of caffeine. This isn’t surprising, considering that when coffee beans are roasted, ground, and extracted in hot water, there are literally hundreds of other compounds dissolved along with caffeine.

REFERENCES

1. Bucci, L.R. (2000). Selected herbals and human exercise performance. American Journal of Clinical Nutrition, 72, 624S-636S.

2. Dulloo, A.G., Duret, C., Girardier, L., Mensi, N., Fathi, M., Chantre, P., & Vandermander, J. (1999). Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24 hour energy expenditure and fat oxidation in humans. American Journal of Clinical Nutrition, 70 1040-1045.

3. Dulloo, A.G., Seydoux, J., Giradier, L., Chantre, P., & Vandermander, J. (2000). Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. International Journal of Obesity and Related Metabolic Disorders, 24, 252-258.

4. Romijn, J.A., Coyle, E.F., Sidosis, L.S., Zhang, X.J., & Wolfe, R.R. (1995). Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. Journal of Applied Physiology, 79, 1939-1945.

5. Costill, D.L., Dalsky, G.P., & Fink, W.J. (1978). Effects of caffeine ingestion on metabolism and exercise performance. Medicine & Science in Sports, 10, 155-158.

6. Spriet, L.L. (1995). Caffeine and performance. International Journal of Sport Nutrition, 5, S84-99.

7. Graham, T.E., Hibbert, E., & Sathasivam, P. (1998). Metabolic and exercise endurance effects of coffee and caffeine ingestion. Journal of Applied Physiology, 85, 883-889.

8. Direction de la Pharmacie et du Medicament (DPM). 1992. Bulletin Officiel (Fascicule special) No. 90/22 bis. [English edition]. Paris: Ministere des Affaires Soicales et de la Solidarite.

9. Haye, B. (1985). Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Molecular and Cellular Endocrinology, 50, 43-41.

WARNING

Do not use SlimBurn Original if you are pregnant or nursing, or if you have been treated for or if you have been diagnosed with high blood pressure, heart liver, thyroid or psychiatric disease, diabetes, anaemia, nervousness, anxiety, depression, seizure, stroke or difficulty in urination due to prostate enlargement.

Consult your doctor if you are taking MAO inhibiters or any other prescription drugs. Discontinue use & consult your doctor if sleeplessness, headache, heart palpitations or tingling sensations occur. Not intended for use by persons under the age of 18. Improper use may be hazardous to a person's health. Note: Guarana Ext. contains caffeine. Keep out of the reach of children.

Manufactured in the EU to the highest standards exclusively for NSSTM SlimBurn Original is not intended to treat diagnose, cure or prevent any disease, always read the bottle. DO NOT EXCEED MORE THAN 4 CAPSULES IN ANY 24HR PERIOD

 
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